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(Peptide Gurus) By mimicking the part of FOXO4 that binds p53, FOXO4-DRI competes for that interaction, frees p53, causes its nuclear exclusion and triggers apoptosis in the senescent cell, thereby selectively reducing senescent cell burden

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This effect is particularly promising for those with type 2 diabetes, as obesity often complicates the management of the condition

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Growth hormone secretagogues: Biology and clinical potential

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doi: 10.2337/diacare.10.1.1 12 HemmingsenBLundSSGluudCVaagAAlmdalTHemmingsenCet al

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Arlington, VA: American Diabetes Association (2021)

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